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。缺乏长期资本和有效风险分担机制，尤其对中小企业而言现金流约束突出。三是企业组织能力不足，不会投。前沿判断能力、跨学科组织能力、平台支撑能力不足，导致难以把基础研究做成体系化、可持续的能力建设。　　第四，从趋势看，国家正在把企业更深地融入基础研究体系，但总体仍处在破题阶段。国家开始推动企业从应用端参与走向源头端出题。比如2025年6月，国家自然科学基金民营企业创新发展联合基金签署，首批4家民营企业

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